To celebrate their 50th anniversary, four childhood friends take on the challenge of crossing America on Route 66. The epic journey is 3945 km long and takes us from Chicago to Santa Monica, California. Jean-Loup, François, Norman and Nicolas travel the road by motorcycle and cross 8 states and 3 time zones. Our friends discover characters shaped by Route 66 who reveal their secrets and their past lives along this mythical road. This journey becomes a pilgrimage and an ode to life and friendship.